Can I use a Gen 4 NVMe SSd in a Gen 2 slot?

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Parts needed to install a device into a slot, Parts needed to OptiPlex 3050 support for PCIe SSD hard drives · Frequently

ssd m2 slot NVMe SSD 50% slower on socket 1

mechanical orange slot expansion slot is the specification for on-board internal expansion cards on a motherboard Intel first introduced